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it depends on the needs of your audience (customers), and on the size of
the documentation, as well your own technology to produce it yourself or to
let it print.
The paper size is always a compromise.
If you use standard sizes, the resulting books may fit into the book
boards, and it is easy to produce them.
Do you print the books yourself?
In this case, you have the opportunity to provide a documentation in a
size, best fitting the needs of the documentation design.
If you feel 19x21 it appropriate, take it.
If you produce PDF files, and the clients print the documents themselves, I
would prefer a layout, fitting as well A4 as letter size. (This is for
international audience.)
If it is a small documentation (up to 32 pages A5), I would produce A5
booklets.
